Aminozuren helpen bij reumatische aandoeningen
Specifieke aminozuren worden door veel mensen met artrose, reumatoïde artritis en fibromyalgie gebruikt om de klachten te bestrijden. Lees hier waarom deze aminozuren daar zo geschikt voor zijn.
Bindweefsel
Bindweefsel is weefsel dat bestaat uit vezels die krachten van het bewegen opvangen. Dit komt eigenlijk neer op al het weefsel in het lichaam. Structuren die vallen onder bindweefsel zijn onder meer, botten, kraakbeen, spieren, pezen, gewrichtsbanden, gewrichtskapsel, gewrichtskraakbeen.
Eiwitten worden in al ons bindweefsel gevonden. Eiwitten bestaan uit aminozuren. In de natuur zijn ongeveer 500 verschillende aminozuren geïdentificeerd, waarvan een beperkt aantal (20) in menselijke eiwitten voorkomt.
Specifieke aminozuurverbindingen, vitaminen & mineralen zorgen er voor dat ons lichaam wordt voorzien van bouwstenen die die het bindweefsel ondersteunen, gezonde gewrichten bevorderen en de aanmaak van nieuw (gewrichts)kraakbeen bevorderen [1]. Uit ander onderzoek is bovendien gebleken dat mangaan helpt bij de normale vorming van bindweefsel [2], en koper bijdraagt tot de instandhouding van normale bindweefsels [3].
Aanmaak van nieuwe weefsels
In voeding zitten eiwitten. Eiwitten bestaan uit aminozuren. Bij de spijsvertering worden de aminozuren onder invloed van enzymen, uit voeding vrijgemaakt. De aminozuren worden via de darmhaarvaten en de poortader naar de lever gevoerd. Een deel van de aminozuren zal de lever onveranderd verlaten, een deel zal in de lever worden omgezet in andere aminozuren (transaminering).
Uit de vrijgekomen aminozuren kan het organisme zijn eigen specifieke eiwitten opbouwen. Het aanmaken (de synthese) van eiwitten binnen een organisme wordt eiwitsynthese genoemd.
Hoe gaat eiwitsynthese in zijn werk
De fibroblast (in bindweefsel) is de actieve cel, waaraan ribosomen hechten die zorgen voor de eiwitsynthese. In het gewrichtskraakbeen is de chondroblast hiervoor verantwoordelijk (chondroblasten zijn feitelijk gespecialiseerde fibroblasten).
Chrondoblasten produceren de actieve vorm van de kraakbeencellen, aangezien ze alle componenten van de kraakbeenmatrix kunnen synthetiseren (chrondoblasten zijn voorlopers van de chondrocyten, de eigenlijke kraakbeencellen).
Fibroblasten zijn de belangrijkste cellen van het bindweefsel (fascie, pezen, ligamenten, gewrichtsbanden, gewrichtskapsel). Fibroblasten zijn verantwoordelijk voor de synthese van alle elementen van de extracellulaire matrix; dus zowel het collageen (niet elastische vezel die zorgt voor de stevigheid van het weefsel), elastische en reticulaire vezels als de glycosaminoglycanen en de glycoproteïnen van de grondsubstantie (matrix).
Aminozuren helpen
Productie van bindweefsels is het hoogste in de leeftijd tot 25 jaar. Daarna kan een geleidelijke achteruitgang van de collageenvezels in weefsels ontstaan.
In vivo onderzoek uitgevoerd aan de universiteit van Rochester Medical Center (USA), bevestigt de unieke voordelen van specifieke aminozuren in ondersteuning van gezonde gewrichten door regeneratie van kraakbeen en zijn belangrijke anti-inflammatoire (ontstekingsremmende) werking [4], terwijl in andere studies is aangetoond dat de behandeling van artrose en reumatoïde artritis met aminozuren zeer effectief blijkt te zijn, die het bindweefsel ondersteunen en gezonde gewrichten bevorderen [5], een positief effect hebben op gewrichtspijn reductie en de gewrichtsfunctionaliteit verbeteren [6].
Fibromyalgie, een niet-gewricht gebonden ziektebeeld, valt in de categorie wekedelenreuma. Een veeltal studies bevestigt de werkzaamheid van aminozuren, die het bindweefsel ondersteunen en gezonde gewrichten bevorderen. Deze gegevens omvatten in-vitro, in vivo en meervoudige placebo-gecontroleerde klinische studies [7].
Waar zijn deze aminozuren verkrijgbaar…
[1] Voetnoot Studies
Jiang, et al. 2014. Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21. T.E.
McAlindon 2011, Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolisate: a pilot randomized controlled trial.
Moskowitz, R., 2000. Role of collagen peptides in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
[2] Voetnoot Studies
European Food Safety Authority (EFSA), 2010. Scientific Opinion on the substantiation of health claims related to manganese and reduction of tiredness and fatigue (ID 312), contribution to normal formation of connective tissue (ID 404) and contribution to normal energy yielding metabolism (ID 405) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. DOI: 10.2903/j.efsa.2010.1808.
[3] Voetnoot Studies
European Food Safety Authority (EFSA) 2009. Scientific Opinion on the substantiation of health claims related to copper and protection of DNA, proteins and lipids from oxidative damage (ID 263, 1726), function of the immune system (ID 264), maintenance of connective tissues (ID 265, 271, 1722), energy-yielding metabolism (ID 266), function of the nervous system (ID 267), maintenance of skin and hair pigmentation (ID 268, 1724), iron transport (ID 269, 270, 1727), cholesterol metabolism (ID 369), and glucose metabolism (ID 369) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. DOI: 10.2903/j.efsa.2009.1211.
[4] Voetnoot Studies
Dar Q.A. et al. 2014, Oral hydrolysed type I collagen induces chondroregeneration and inhabits synovial inflammation in murine posttraumatic osteoarthritis , Osteoarthritis and Cartilage. 24:5532-5533.
[5] Voetnoot Studies
Moskowitz, R., 2000. Role of collagen peptides in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
{6] Voetnoot studies
Jiang JX. et al. (2013). Treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study. Agro FOOD Industry Hi Tech, Vol 25(2):19-23.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen peptides, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
[7] Voetnoot studies
Jiang, et al. 2014. Collagen Peptides for Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.
Van Vijven J.P.J. et al., 2012. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20: 809-821.
Henrotin Y. et al., 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken five products. Osteoarthritis and Cartilage, 19: 1-21.
Ragle R.L. et al., 2012. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs & Aging, 29: 717-731.
Moskowitz, R., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
Clark, K.L. et al., 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activityrelated joint pain. Current Medical Research and Opinion, 24: 1485-1496
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