Bewust leven met reuma
Reuma is een verzamelnaam voor aandoeningen waarbij het lichaam een afweerreactie (immuunreactie) geeft tegen normaal, eigen lichaamsweefsel, resulterend in ontstekingen. Het Reumafonds definieert reuma als alle aandoeningen die men kan hebben aan het bewegingsapparaat (gewrichten en de omliggende pezen, gewrichtsbanden en spieren) uitgezonderd klachten ten gevolge van een ongeval.
Onder die definitie vallen dus patiënten met reumatoïde artritis (420.000 in Nederland), maar ook de patiënten met artrose (gewrichtsslijtage; 1,1 miljoen mensen) en die met fibromyalgie (diffuse pijn in spieren, banden, pezen en kapsel om gewrichten, doorgaans zonder ontsteking; 240.000 mensen in Nederland). Maar er zijn meer vormen van reuma (meer dan 100 verschillende) waaronder allemaal aandoeningen aan gewrichten, spieren, pezen en kraakbeen vallen, waarvan hier genoemd: Acuut reuma, Artritis Psoriatica, Ziekte van Behçet, Bursitis, jicht, Lupus Erythematodes, De ziekte van Lyme, MCTD, Osteoporose, Het fenomeen van Raynaud, SCCH, Het syndroom van Sjögren.
Zoals bij veel chronische aandoeningen is het moeilijk om één enkele oorzaak van reuma aan te wijzen. Reuma is een auto-immuunziekte waarbij pijnlijke ontstekingen in de gewrichten zitten. Bij een auto-immuunziekte maakt het lichaam antistoffen aan die een ontsteking kunnen veroorzaken. De oorzaak kan erfelijk bepaald zijn, óók veroorzaken sommige virussen en bacteriën reuma, kan stress een factor zijn, is langdurige zware lichamelijke belasting een boosdoener en lijkt het erop dat omgevingsfactoren zoals roken en overgewicht een rol spelen. In veel gevallen lijkt de oorzaak echter een combinatie waarin meerdere van bovenstaande factoren in meer of mindere mate een rol spelen.
Gewrichtsfunctie en aminozuren
Een grote hoeveelheid wetenschappelijke studies bevestigt de werkzaamheid van aminozuren, die het bindweefsel ondersteunen en gezonde gewrichten bevorderen. Deze gegevens omvatten in-vitro, in vivo en meervoudige placebo-gecontroleerde klinische studies [1]. Uit studie, double-blind randomized, placebo-controlled, is voorts gebleken dat aminozuren de aanmaak van nieuw kraakbeen bevorderen [2].
Eiwitten worden in al ons bindweefsel gevonden. Zo zit het in onze gewrichten, het kraakbeen, en botten. Eiwitten bestaan uit aminozuren. In de natuur zijn ongeveer 500 verschillende aminozuren geïdentificeerd, waarvan een beperkt aantal in menselijke eiwitten voorkomt.
Consumptie van uitgekiende aminozuurverbindingen, vitaminen, mineralen zal er voor zorgen dat ons lichaam volop wordt voorzien van bouwstenen, die goed zijn voor de aanmaak van kraakbeen (in de gewrichten), een rol spelen bij de botaanmaak en van belang zijn voor de normale vorming van bindweefsel in kraakbeen en botten (eiwitten/mangaan).
In klinische studies is bovendien bevestigd dat een dagelijkse inname van ca. 8g aminozuren (collagen derivatives) een positief effect had op gewrichtspijn reductie en de gewrichtsfunctionaliteit verbeterde [3]. In weer andere studies is bevestigd dat de combinatie van genoemde aminozuren, degeneratie van het gewricht helpt te voorkomen en pijn helpt te verminderen [4].
[1] Voetnoot Studies
Henrotin Y. et al., 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken five products. Osteoarthritis and Cartilage, 19: 1-21.
Moskowitz, R., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.
Jiang, et al. 2014. Collagen Peptides for Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.
Van Vijven J.P.J. et al., 2012. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20: 809-821.
Ragle R.L. et al., 2012. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs & Aging, 29: 717-731.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
Clark, K.L. et al., 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activityrelated joint pain. Current Medical Research and Opinion, 24: 1485-1496.
[2] Voetnoot Studies
Jiang, et al. 2014. Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.
T.E. McAlindon 2011, Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolisate: a pilot randomized controlled trial.
[3] Voetnoot Studies
Jiang JX. et al. (2013). Treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled study. Agro FOOD Industry Hi Tech, Vol 25(2):19-23.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen peptides, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
[4] Voetnoot Studies
Van Vijven, J.P.J. et al., 2012, Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review, Osteoarthritis and Cartridge, 20(8): 809-821.
Ragle, R.L., and Sawitzke, A.D., 2012, Nutraceuticals in the management of osteoarthritis: a critical review, Drugs Aging, 29(9): 717–731.
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