Nieuwe behandelingen voor artrose

Artrose komt in Nederland dikwijls voor, bij ouderen, maar ook steeds vaker bij relatief jonge mensen. Artrose is een aandoening waarbij het kraakbeen in de gewrichten kwetsbaar en dun wordt en het gewricht ontstoken raakt. Daardoor treedt schade op in het gewricht. De aandoening geeft pijnklachten waardoor de patiënt zich steeds moeilijker kan (voort)bewegen. Behandeling is op dit moment vooral gericht op pijnbestrijding. Als dat niet meer helpt, rest een operatie waarbij de patiënt een gewrichtsprothese krijgt. Deze gewrichtsprothese heeft echter een beperkte houdbaarheid.

Stamceltherapie

Artrose kan in de toekomst misschien worden behandeld met stamceltherapie. Het injecteren van lichaamseigen stamcellen in beschadigde gewrichten laat hoopgevende resultaten zien. Dat dit zo is bleek uit onderzoek van Erasmus MC in Rotterdam. Uit het onderzoek bleek dat de stamcellen als een soort eiwitfabriekjes werkten die ontstekingsremmende factoren en groeifactoren maakten. De cellen hadden positieve effecten op de ontstekingen en de kraakbeenafbraak. In samenwerking met de afdeling radiologie werd ontdekt dat de cellen na injectie betrekkelijk lang aanwezig bleven in de gewrichten. Tevens werd de pijn iets minder. Vervolgonderzoek moet uitwijzen of de gevonden effecten zich ook bij mensen voordoen.

Bones Vitalis Gewrichten

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Kweken van blijvend kraakbeen

Onderzoekers van de Universiteit Twente (2014) zijn er voor het eerst in geslaagd blijvend kraakbeen te kweken dat zijn vorm ook in het lichaam behoudt. De cellen werden gekweekt bij een lage zuurstofconcentratie van tweeënhalf procent. De gouden standaard voor het kweken van kraakbeen was altijd een concentratie van 21 procent, net als de buitenlucht. Dat is eigenlijk niet natuurlijk, omdat in het lichaam die concentratie een stuk lager is. De onderzoekers gaan door met onderzoek, omdat het de verwachting is dat het kraakbeen ook in het lichaam van de mens blijft.

Wat kunnen aminozuren voor jou betekenen

Een grote hoeveelheid wetenschappelijke studies bevestigt de werkzaamheid van aminozuren, die het bindweefsel ondersteunen en gezonde gewrichten bevorderen. Deze gegevens omvatten in-vitro, in vivo en meervoudige placebo-gecontroleerde klinische studies [1]. Uit studie, double-blind randomized, placebo-controlled, is gebleken dat aminozuren de aanmaak van nieuw kraakbeen bevorderen [2].

In wetenschappelijke reviews [3] over pijn in gewrichten is geconcludeerd dat dat bepaalde voedingsstoffen (collagen aminozuurverbinding), in vergelijking met andere voedingsstoffen, bijzonder voordelig zijn voor mensen met gewricht gezondheidsproblemen, met name voor het verminderen van gewricht ongemak.

Meerdere studies [4] hebben bovendien bevestigd dat patiënten met grote slijtage aan gewrichten bovenmatig profiteerden van dagelijkse inname van collagen aminozuurverbinding (eiwitten).

Ontdek meer…

[1] Voetnoot Studies

Henrotin Y. et al., 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken five products. Osteoarthritis and Cartilage, 19: 1-21.

Moskowitz, R., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.

Jiang, et al. 2014. Collagen Peptides for Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.

Van Vijven J.P.J. et al., 2012. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20: 809-821.

Ragle R.L. et al., 2012. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs & Aging, 29: 717-731.

Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.

Clark, K.L. et al., 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activityrelated joint pain. Current Medical Research and Opinion, 24: 1485-1496.

[2] Voetnoot Studies

Jiang, et al. 2014. Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.

T.E. McAlindon 2011, Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolisate: a pilot randomized controlled trial.

[3] Voetnoot studies

Henrotin Y. et al., 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken five products. Osteoarthritis and Cartilage, 19: 1-21.

Ragle R.L. et al., 2012. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs & Aging, 29: 717-731.

Van Vijven J.P.J. et al., 2012. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20: 809-821.

[4] Voetnoot studies

Moskowitz, R., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.

Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient,collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.

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