Alcohol, fibromyalgie en kwaliteit van leven
Onderzoekers van de Universiteit van Michigan in de US hebben fibromyalgie patiënten onderzocht om de associatie tussen alcohol en de bijbehorende symptomen te onderzoeken. Gematigde drinkers hadden betere scores voor de lichamelijke functie, vermogen om te werken, het aantal gemiste werkdagen, vermoeidheid en pijn, dan mensen die zich onthouden. Teveel alcohol keerde het effect om [1].
Matige drinkers die tussen drie en zeven standaarddrankjes per week nemen, lijken dus minder pijn te hebben dan geheelonthouders of zware drinkers, zelfs wanneer de resultaten gecontroleerd werden met confounding [2] factoren. Vergelijkbare resultaten werden gezien voor de kwaliteit van het leven, waaronder sociaal functioneren, vitaliteit en algemene gezondheid.
Uitdrukkelijk wordt gemeld door de onderzoekers dat óók gematigd alcoholgebruik naast deze positieve, natuurlijk ook negatieve gevolgen kan hebben voor de gezondheid. Maar in geval van fibromyalgie heeft matig drinken volgens deze studie dus ook positieve effecten, vooral wanneer dit gebeurt in combinatie met een gezonde levensstijl, regelmatige lichaamsbeweging en niet roken.
Hoofdonderzoeker Dr. Terry H. Oh legt uit waarom gematigd alcohol consumeren, dit effect kan hebben. Alcohol bindt zich namelijk aan de remmende neurotransmitter, Gamma-aminoboterzuur (GABA). Dit zorgt ervoor dat de pijnoverdracht vermindert. Dat matige drinkers minder symptomen hebben kan echter ook worden veroorzaakt door verbeterde stemming, socialisatie en spanning, Er zijn nog veel vragen over hoe dit gebeurt, aldus Oh.
Fibromyalgie en aminozuren
Een grote hoeveelheid wetenschappelijke studies bevestigt de werkzaamheid van aminozuren, die het bindweefsel ondersteunen en gezonde gewrichten bevorderen. Deze gegevens omvatten in-vitro, in vivo en meervoudige placebo-gecontroleerde klinische studies [3].
Fibromyalgie is een niet-gewrichtsgebonden ziektebeeld. Het valt in de categorie wekedelenreuma. De aandoening kenmerkt zich onder meer door spierstijfheid en pijn in gewrichten, Fibromyalgie patiënten kunnen ’s nachts wakker worden van de pijn of moeilijk in slaap komen door de pijn.
Met weke delen duidt men het weefsel aan dat andere structuren en organen van het lichaam verbindt, ondersteunt of omvat. Hieronder wordt o.m. verstaan: de omgeving van de gewrichten, spieren en vezelig bindweefsel, pezen (de aanhechtingsplaatsen van de spieren aan de pezen), ligamenten en zenuwen.
In een klinisch studie is bevestigd dat een dagelijkse inname van specifieke aminozuren (ca. 8g per dag), een positief effect had op gewrichtspijn reductie en de gewrichtsfunctionaliteit verbeterde [4], terwijl in andere studies de gunstige effecten van deze aminozuren is bevestigd ter zake behoud van gezonde gewrichten en het verminderen van pijn [5].
Lees meer over deze specifieke aminozuren…
Aminozuren zijn als voedingssupplement te verkrijgen. Voedingssupplementen worden als levensmiddel geclassificeerd. Ze hebben dan ook – afgezien van eventuele voedselallergie of voedselintolerantie – geen bijwerkingen.
Fibromyalgie komt ongeveer bij twee op de honderd volwassenen voor. 90% van de fibromyalgie patiënten betreft vrouwen tussen de 20 en 60 jaar oud. Het syndroom openbaart zich meestal tussen het 25e en 40e levensjaar. De klachten die kunnen oplopen zijn pijn in spieren en pezen, gewrichten en andere bindweefsels, ook gaat het vaak hand in hand met vermoeidheid, slaapproblemen, darmkrampen en depressie.
1. Voetnoot Studies
Chul H Kim, et al 2013. Association between alcohol consumption and symptom severity and quality of life in patients with fibromyalgia. Arthritis Research & Therapy, 2013; 15 (2): R42; DOI: 10.1186/ar4200.
2. Voetnoot Confounding
Confounding is een belangrijk en veelvoorkomend probleem in observationeel, niet-gerandomiseerd onderzoek naar de effecten van geneesmiddelen of schadelijke blootstellingen (determinanten), in het onderhavige geval dus naar de effecten van alcoholgebruik. Confounding is het effect waarbij een derde variabele een relatie vertoont met zowel de onafhankelijke variabele als de afhankelijke variabele, maar deze variabele vormt geen ‘tussenschakel’ tussen de onafhankelijke en afhankelijke variabele.
3. Voetnoot studies
Jiang, et al. 2014. Collagen Peptides for Treatment of Knee Osteoarthritis: A Double-Blind Randomized, Placebo-Controlled Study. Agro Food Industry Hi Tech 25(2): 20–21.
Van Vijven J.P.J. et al., 2012. Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis and Cartilage, 20: 809-821.
Henrotin Y. et al., 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken five products. Osteoarthritis and Cartilage, 19: 1-21.
Ragle R.L. et al., 2012. Nutraceuticals in the management of osteoarthritis: a critical review. Drugs & Aging, 29: 717-731.
Moskowitz, R., 2000. Role of collagen hydrolysate in bone and joint disease. Seminars in Arthritis and Rheumatism, 30: 87-99.
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
Clark, K.L. et al., 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activityrelated joint pain. Current Medical Research and Opinion, 24: 1485-1496
4. Voetnoot studies
Benito-Ruiz P. et al., 2009. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen peptides, for improving joint comfort. International Journal of Food Sciences and Nutrition, 60:99-113.
5. Voetnoot studies
Oesser, S. et al. (2003). Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine Chandrocytes Cultured with Degraded Collagen. Cell Tissue Research, 311: 393-399.
Oesser, S., et al. (1999). Oral Administration of 14C Labelled Gelatine Hydroslysate. Journal of Nutrition, 129: 1891-1895.
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